The first store was opened in 1963 by Stanley and Sidney Goldstein, and Ralph Hoagland, in Lowell, Massachusetts, as the Consumer Value Store. By 1964 there are 17 Consumer Value Stores throughout New England.
In 1967, CVS opens its first stores with a built-in pharmacy.
Today, CVS has over 9,600 outlets located throughout 49 US states, Puerto Rico, DC, and Brazil. Most stores feature a pharmacy, and in jurisdictions that allow it, stores sell beer and alcohol. In 2014, CVS announced that it stop selling cigarettes at its shops.